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KMID : 1103920060120030444
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Korean Journal of Hepatology
2006 Volume.12 No. 3 p.444 ~ p.448
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A Case of Bell`s Palsy Associated with Peginterferon Alfa-2a and Ribavirin Therapy for Chronic Hepatitis C Virus Infection
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Lee Moo-Yeol
Cho Hoon
Kim Yeong Muk
Lee Joon Sang
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Abstract
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Pegylated interferon alfa-2a (PEG-IFN) and ribavirin combination therapy is the first line treatment for chronic HCV infection. There are four reports of Bell’s palsy associated with interferon-α (IFN-α) and ribavirin therapy. We report here a case of Bell’s palsy that occurred in a patient with chronic HCV infection during combination PEG-IFN and ribavirin therapy. The patient was 49-year-old man with chronic hepatitis C for 2 years. The liver biopsy showed grade 1 and stage 1. Therapy with PEG-IFN (Pegasys) 180 μg/week and ribavirin 1200 mg/day was initiated. After 3 weeks of treatment, the patient showed a loss of muscular tone on the left side of his face. A diagnosis of Bell’s palsy was made, and the PEG-IFN and ribavirin therapy was stopped. Prednisolone 45 mg/d was given and then tapered for 8 weeks. His palsy improved
over 6 weeks.
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KEYWORD
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Chronic hepatitis C, Pegylated interferon alfa-2a, Bell palsy, Complications
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